Green Synthesis of Pyrimidine Derivative

I- pyrimidine derivative and its biological evaluation

This study describe the organic synthesis of 2-iodobenzamido (2-N-nitrobenzen-5, 6, 7, 8 tetrahydrobenzothieno [2, 3d]) pyrimidine -4-(3H) one as an example for some pyrimidine derivative used a new series of as potential cancer chemotherapeutic agents. The precursor derivative is α-(2-iodobenzamido)-β (4-nitrophenyl)-N[3-ethoxy-carbonyl-4, 5, 6, 7-tetrahydrobenzothiophen-2-l] acrylic acid amid...

Synthesis, Analgesic and Ulcerogenic Activity of Novel Pyrimidine Derivative of Coumarin Moiety

A novel series of 3-(2-amino-6-pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (5a-5j) were synthesized from 3-acetyl-6-bromo-2H-chromen-2-one (3). The structures of the synthesized compounds were elucidated by IR, H-NMR, C-NMR, and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo analgesic activity at a dose of 20 mg/kg body weight. Among them, compounds 5a, 5b and 5...

Prebiotic Synthesis of Pyrimidine Nucleosides

Electron as potential and green catalyst in the multicomponent synthesis of pyrano [2, 3-d] pyrimidine derivatives

An electroorganic reaction for the synthesis of 7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-pyrano[2, 3-d] pyrimidine-6-carbonitrile and ethyl-7-amino-2, 4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-pyrano[2, 3-d] pyrimidine-6-carboxylate derivatives are described, using an electrogenerated base of the anion of malonitrile or ethylcyanoacetate. This one-pot, three-component condensation of an a...

Nanocrystalline SiO2–HClO4: A novel, efficient and green catalyst for the three-component synthesis of pyrimidine derivatives

Nanocrystalline SiO2–HClO4, as a newly reported catalyst, has been used as an efficient and reusable catalyst for the synthesis of pyrimidine derivatives. The procedure can be successfully applied to the efficient synthesis of mono substituted pyrimidine derivatives, using triethyl orthoformate, ammonium acetate, methyl ketone derivatives. In practice, this method is a combination of a satisfac...